Yes, studies have shown that SSRIs can increase levels of a protein called brain-derived neurotrophic factor (BDNF), which is involved in learning and memory. In animal studies, SSRIs have been found to induce the production of BDNF in the hippocampus and other brain regions associated with memory and emotion. Additionally, some human studies have found that SSRIs can increase BDNF levels in the blood. However, more research is needed to better understand how SSRIs affect BDNF levels in humans.

Which antidepressant increases BDNF most?

According to a study published in the International Journal of Neuropsychopharmacology, the antidepressant drug fluoxetine (Prozac) was found to have the most significant effect on increasing brain-derived neurotrophic factor (BDNF). The study found that fluoxetine was able to increase BDNF levels in the hippocampus of rats after just one week of administration. Other antidepressants, including paroxetine, sertraline, citalopram, and escitalopram, were also found to increase BDNF levels, but they had a smaller impact than fluoxetine.

Do antidepressants affect BDNF?

Yes, antidepressants can affect levels of Brain-Derived Neurotrophic Factor (BDNF). Studies have found that antidepressant use can increase BDNF levels, which may help to explain some of the mood-stabilizing effects of these medications. Additionally, some research suggests that higher levels of BDNF may be associated with a better response to antidepressants. However, more research is needed to better understand the exact relationship between antidepressant use and BDNF levels.