Eating papaya can have some side effects, especially if it is consumed in large amounts. These include indigestion, bloating, abdominal discomfort, and nausea. Papaya can also interact with certain medications, so it is important to speak with a doctor before eating it if you are on any medications. Eating too much papaya can also cause an allergic reaction for some people, so it is important to be aware of any symptoms that may appear.