A couple of questions

What stimulates BDNF release?

The best characterized stimuli are patterns of neuronal electrical activity like prolonged depolarization, high-frequency stimulation (HFS), or theta-burst stimulation (TBS) that trigger BDNF release in developing and mature neurons (Edelmann et al.Sep 18, 2563 BE

What stimulates BDNF production?

Rigorous exercise has been shown to increase BDNF levels. A study published in 2011 found that three weeks of high-intensity cycling and five weeks of aerobic exercise improved cognitive functioning and increased levels of BDNF.

How do you trigger BDNF?

Eat These BDNF Foods Dark chocolate, blueberries, and extra-virgin olive oil are high-polyphenol foods that are proven to increase BDNF and support brain health[10][38][46][46]. Butyrate, a short-chain fatty acid found in butter also appears to raise BDNF[47].

What increases BDNF the most?

Exercise is the fastest and most effective way to boost BDNF levels, and improve learning, memory and mood (1, 2, 3, 4). In just 5 weeks, mild-intensity exercise significantly increased BDNF levels and reversed cognitive decline in old rats (62).

What drugs increase BDNF?

Antidepressant drugs, e.g. SSRIs, increase BDNF in the hippocampus and PFC. Ketamine rapidly increases BDNF protein levels in the hippocampus. Ketamine elicits hippocampal potentiation dependent on BDNF expression. BDNF is required for the antidepressant effects of traditional antidepressant drugs and ketamine.

Do SSRIs increase BDNF?

BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression.

Does caffeine increase BDNF?

Interestingly, caffeine increases BDNF levels (Costa et al. 2008; Sallaberry et al. 2013) and BDNF can induce NMDAR‐independent LTP (Kang & Schuman 1995).

Does curcumin increase BDNF?

Specifically, curcumin at doses of 50 and 100 mg/kg (p.o.) increased BDNF protein levels by 78.0% and 95.1%, respectively, compared to the control group.